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Its true that they talk about it in the gym, confirms Teresa (not her real name), a personal trainer at an exclusive sports center in Madrid, Spain

When you lose weight, change your diet, and exercise regularly, you also boost feel-good hormones like dopamine, serotonin, endorphins, and oxytocin

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At week 36, the following differences were observed for change in 24-hour diastolic blood pressure from baseline relative to placebo therapy: Tirzepatide 5 mg: -2.0 (95% CI, -3.6 to -0.3) mmHg Tirzepatide 10 mg: -2.9 (95% CI, -4.5 to -1.3) mmHg Tirzepatide 15 mg: -0.5 (95% CI, -2.0 to 1.1) mmHg Further analysis suggested these results were consistent across subgroups defined by clinically relevant factors, including age, sex, BMI, and hypertension-related factors

But each step also introduces more injection days, more opportunities for measurement error, and more deviation from studied protocols