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Glycemic category (normoglycemia, prediabetes or type 2 diabetes) was determined by investigators on the basis of available information (for example, medical records, concomitant medication, and blood glucose variables) and in accordance with American Diabetes Association criteria 30 , which for prediabetes includes fasting plasma glucose levels of 100 mg dl 1 (5.6 mmol l 1 ) to 125 mg dl 1 (6.9 mmol l 1 ) or HbA 1c levels of 5.76.4% (3947 mmol l 1 ), and for type 2 diabetes includes fasting plasma glucose levels of 126 mg dl 1 (7.0 mmol l 1 ) or HbA 1c levels 6.5% (48 mmol l 1 )
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J., Baronowsky, E
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Pharmacokinetics and exposure All seven completers having undergone PET assessments at the end of treatment were exposed to SAR425899 plasma levels comparable to other clinical studies having applied similar dose levels
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