Under high glucose conditions, GLP-1 at 100 nM enhanced the expression of osteogenic markers (collagen type I ( COL1 ), osteocalcin ( OCN ), runt-related transcription factor 2 ( RUNX2 ) and activated the Wingless-type MMTV integration site family member ( Wnt )/-catenin pathway, known to play a key role in osteogenesis, as shown by Li et al
Components of the extracellular matrix, the basement membrane, and interstitial metabolites may act as diffusion barriers or local redox buffers that restrict the movement of oxidized lipids, iron species, and paracrine death signals
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