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Preclinical and clinical data suggest that FXR and PPAR dual modulators can improve insulin sensitivity, reduce hepatic steatosis, and attenuate fibrosis, which may complement the actions of GLP-1/GIP/GCG receptors agonists
doi:10.1155/2012/736837 52
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Patients with a history of pancreatitis should be evaluated carefully before initiating treatment with Semaglutide / Cyanocobalamin Injection, as GLP-1 receptor agonists have been associated with acute pancreatitis in post-marketing surveillance, though a definitive causal relationship has not been established
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