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A significant limitation of the current clinical evidence is its reliance on post-hoc analyses of cardiovascular outcome trials and large-scale retrospective studies

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To date, liraglutide, semaglutide, albiglutide, and dulaglutide (but not exenatide or lixisenatide) have shown superiority compared to placebo for reduction in a 3P-MACE endpoint (62)

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These include a Section 402 Part D demonstration and a Center for Medicare and Medicaid Innovation demonstration

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OGTT/HOMA, oral glucose tolerance test/homeostasis model assessment

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