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*Table: Reported Influences on Libido with GLP-1/GIP Agonists* A 2022 study in Diabetes, Obesity and Metabolism on tirzepatide noted that quality of life measures related to physical function and self-esteem improved significantly, which often correlates with better sexual health

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While some patients may benefit from combining HRT and semaglutide, others have noted some drawbacks

We need frequent B12 in order to keep brain and body healthy

This leads to a state of relative deficiency that severely impairs cellular function

[2] [3] Tirzepatide carries warnings for several serious potential adverse effects, including acute pancreatitis, acute kidney injury (particularly from dehydration due to gastrointestinal effects), and acute gallbladder disease (including gallstones and cholecystitis)