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Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16
Indeed, the average fitness score of the Mla pathway genes negatively correlated with the molecular weight of the antibiotic (Fig
doi: 10.1111/mpp.12661 12 DecrosA.MahillonM.GenardM.LienardC.Lima-MendezG.GilmerD.et al
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