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Moreover, a recent study from Guzman and colleagues (39) has shown that, in patients with T2D, treatment with a selective GCGR antagonist, LY2409021, induces a significant increase in hepatic lipid content assessed by magnetic resonance imaging, suggesting that GCGR activation is required to prevent build-up of fat in the hepatocytes
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A third, recent study in JAMA Network Open , from August of 2025, analyzed data from 159,000 people with type 2 diabetes who took semaglutide or tirzepatide (Mounjaro, Zepbound)
doi:10.1253/circj.CJ-16-0152 54
highest concentration of glutathione is found in the liver Promotes p450 phase II conjugation pathways in the liver to support detoxification Maintains healthy lipid metabolism and oxidative status
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