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No validated human dose

6 with the disulfide form of glutathione

An initial 3D model was built in Relion with both C1 and C2 symmetry and used for subsequent 3D classifications and refinements

The D-Phe inversion sits inside the conserved His-Phe-Arg-Trp message tetrapeptide that every melanocortin receptor recognises, and it is the substitution responsible for the markedly prolonged receptor occupancy reported for this analogue relative to alpha-MSH, because inverting that stereocentre removes a favoured chymotrypsin-like cleavage point

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