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Glucagon-like Peptide-1 Receptor Dependent Signaling in Cardiovascular Health and Disease: A Mini-review

[13] Wharton S, Haase CL, Kamran E, Liu A, Mancini J, Neish D, Pakseresht A, Power GS, Christensen RAG

This approach is designed to meet regulatory expectations and, at the same time, reduce two foreseeable risks: inadvertent early pregnancy exposure and metabolic rebound after cessation

The -aminoisobutyric acid at position 8 (proglucagon numbering) replaces the native alanine and protects semaglutide from cleavage by dipeptidyl peptidase-4

10.1016/j.physbeh.2010.11.001 151 VassarR.BennettB

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