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The Korean Journal of Internal Medicine

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This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

AOD-9604 was studied in a Phase IIb obesity trial in the early 2000s, while MOTS-c entered human pilot research only in the last several years

However, the gradual correction of anemia takes place over a period of 90 days