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Avoid crushing or chewing tablets: The tablets should be swallowed whole

Intellia Therapeutics said the FDA lifted a clinical hold on a Phase 3 study of its CRISPR gene-editing therapy for a condition called transthyretin amyloidosis, or ATTR, that mostly affects nerves

Such methodological limitations introduce potential confounding factors, particularly when additional glucose-lowering therapies, such as insulin or metformin, are co-administered

Study authors also noted improvements in health status and exercise tolerance

Subgroup analyses for continuous endpoints in the intention-to-treat were performed using 1,000 multiple imputations using analysis of covariance models, with treatment by BMI groups adjusted for the relevant continuous baseline variable 12