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The difference is driven by retatrutide glucagon receptor activation, which directly stimulates cardiac tissue through a mechanism semaglutide does not engage
Common Side Effects Nausea Diarrhea Vomiting Constipation Stomach pain Decreased appetite Headache Serious Side Effects (Less Common) Pancreatitis Gallbladder issues Kidney problems due to dehydration Serious allergic reactions Vision changes for type 2 diabetes patients Increased heart rate Due to the risk of thyroid C-cell tumors highlighted in animal studies, oral semaglutide is not recommended for people with specific thyroid cancer histories
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FDA clearance to initiate our Phase 2a MOSAIC Trial of ECC4703 and ECC0509 for MASH
