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It works through AMP-activated protein kinase (AMPK) activation, which actually shares some mechanistic overlap with ketosis

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Turrigiano GG, Leslie KR, Desai NS, Rutherford LC, Nelson SB (1998)

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Recommendation (Evidence Strength: Grade C) Systemic (oral) long-term glucocorticoid administration should not be offered

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The extracellular protein non-covalently associates with the transmembrane protein

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