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Common symptoms that may indicate conditions associated with low DHEA-S: Persistent fatigue: Overwhelming tiredness can be due to decreased hormone support for energy metabolism Decreased muscle mass: Reduced strength and muscle tone can result from diminished anabolic support Mood changes: Depression, anxiety, or reduced sense of well-being may result from altered neurosteroid effects in the brain Cognitive difficulties: Problems with memory or concentration can be related to DHEA's role in brain function Reduced libido: Decreased sexual interest may be due to lower testosterone and estrogen production Joint pain: Discomfort in joints, possibly related to reduced anti-inflammatory effects Bone density loss: Gradual weakening of bones can result from decreased hormonal support for bone mineralization Common symptoms that may indicate conditions associated with high DHEA-S in women: Hirsutism: Excessive hair growth in male-pattern locations (face, chest, abdomen) can be due to increased androgen effects Acne: Skin breakouts from increased sebum production may be stimulated by androgens Menstrual irregularities: Infrequent or absent periods can result from a hormonal imbalance affecting ovulation Male-pattern hair loss: Thinning at the crown or temples can result from androgenic effects on hair follicles Insulin resistance: Difficulty processing glucose effectively, potentially leading to weight gain Mood swings: Irritability or aggression can result from fluctuating hormone levels In men, high DHEA-S typically causes fewer noticeable symptoms but may be associated with conditions requiring medical attention

doi: 10.1056/NEJMoa1406656 80 DarsaliaVKleinTNystrmTPatroneC

Seven years down the line is a long time to forecast, but it is clear that these drugs are set to become more affordable and accessible in the coming years, he says.

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Novo Nordisk reported that at least 25,000 people in the US are now starting Wegovy each week

Given the early stages of this therapeutic approach senescence therapeutics will need to overcome challenges related to biomarker identification, target engagement, CNS penetrance and safety