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All use in men or postmenopausal women represents off-label prescribing based on Phase 2 data and clinical experience rather than FDA-approved indications

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Receptors in the amygdala suggest potential interactions between GLP-1 signaling and anxiety or stress processing

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The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy