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Physiological weight loss can help decrease metabolic risk factors and is effective in managing several diseases

The foundational mechanism work has been complemented by translational-research investigations in disease-model systems and by recent contemporary reviews compiling the broader research framework

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for instance, diabetic rats induced with streptozotocin show AD-like brain changes, including A and neuroinflammation (Clark et al., 2012)

Metabolism slows down , leading to a frustrating cycle where diet and exercise seem less effective

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