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Both sit at the preclinical tier mechanistically plausible, supported by cell-culture and animal studies, but not confirmed by controlled human trials

253 Furthermore, when combined with a ferroptosis inducer, FMD can effectively eliminate slow-cycling, chemotherapy-resistant cells, suggesting a potential strategy for enhancing the sensitivity of certain difficult-to-treat cancers to chemotherapy through dietary interventions

Mutations in the superoxide dismutase 1 (SOD1) gene are associated with familial forms of ALS [167]

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