Rapid weight loss outpaces the skins ability to remodel, and substrate availability tightens
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If the liver is metabolically compromised, then the synthesis pathway may be inhibited
Plant J 8:167175 Davletova S, Rizhsky L, Liang H, Shengqiang Z, Oliver DJ, Coutu J, Shulaev V, Schlauch K, Mittler R (2005) Cytosolic ascorbate peroxidase 1 is a central component of the reactive oxygen gene network of Arabidopsis
doi: 10.3390/ANTIOX10081266 207 Roth-WalterFBerni CananiROMahonyLPeroniDSokolowskaMVassilopoulouEet al
It boosts the nitric oxide (NO) system and raises growth factors like VEGF and FGF to help new blood vessels form at injury sites