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In rat models, vitamin D improved cardiac function, reduced oxidative stress markers, and decreased inflammatory cytokines compared to doxorubicin-only treatment [69]

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Depletion of cystine/cysteine reduces intracellular GSH levels and GPX4 activity within the cystine/cysteine-GSH-GPX4 axis, thus causing ferroptosis (18,99)

Materials and methods Ethics statement All animal procedures were approved by the Animal Care Advisory Committee of Sichuan Agricultural University (China, No

18 : 573578 Santarelli M, Granato A, Sbriccoli A, Gobbi G, Janiri L, Minciacchi D