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For effectiveness, opinions are divided

However, the researchers caution that this was not a clinical trial

129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons

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PMID: 25707779

Rotate actives if dryness or reduced response appears, and check with your dermatologist for long-term plans