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The predicted binding mode places neuromedin C along the canonical peptide-binding groove, consistent with the class B1 GPCR two-domain recognition paradigm in which peptide ligands are initially oriented by extracellular receptor elements and subsequently stabilize the active TM architecture required for signaling (Figure 4)

Hanley S

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That theoretical concern also exists for BPC-157 due to its promotion of healing and new blood vessel growth (angiogenesis)

Bibcode:2017PNAS..114E1196C