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Results Establishing a psychoactive dose of psilocybin for metabolic studies To test the bioactivity of psilocybin and determine an appropriate dose for assessing the metabolic effects of psilocybin in mice, we measured the head-twitch response following a single administration of 0.3 mg/kg psilocybin, 1 mg/kg psilocybin, 3 mg/kg psilocybin or vehicle (isotonic saline)

doi:10.1021/acs.molpharmaceut.5b00278 154