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doi:10.1093/aje/kww212

Its core physiological function is to catalyze the methylation of nicotinamide (NAM, a key precursor for NAD+ synthesis) with Sadenosylmethionine (SAM) to produce 1methylnicotinamide (1MNA)

In peptide medicine communities, reported protocols commonly range from 200-500 mcg once or twice daily, often used in short cycles lasting several weeks

Dosing both compounds at the same timemid-day, post-mealresults in blunted metabolic markers and lower substrate utilization efficiency