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Additionally, the potential long-term benefits of GLP-1 therapy on different stages of cognitive impairment, such as MCI and dementia, warrant further exploration
(Note: The manufacturer of Mounjaro , Eli Lilly, has released the same drug tirzepatide under a different brand name, Zepbound, which is FDA-approved specifically for weight loss
A study involving mice also found that the release of free copper ions induced neointimal thickening and contributed to the development of atherosclerotic lesions in damaged rat carotid arteries (62)
Taken together, these findings provide more robust evidence to guide clinical decision-making on sacubitril/valsartan use in HFmrEF and HFpEF, but further trials are needed to better define which patients may derive the greatest benefit
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