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Potential Benefits & Side Effects Observations from phase 2 and phase 3 clinical trials

Visible body composition changes from the combination usually become apparent at weeks 6-8, when AOD 9604 has been active for 2-4 weeks alongside escalating tirzepatide doses

Though the intent of the study was to find the safe maximum dose of mebendazole, a survey of progression free survival in those who received greater than one month of mebendazole found that those who did had 13.1 months progression free survival, compared to 9.2 months progression free survival for those who received less than one month of mebendazole treatment

Baseline matters

Additionally, peptides that have been lyophilized must be kept at low temperatures in order to avoid degradation during the reconstitution process

nitrous oxide exposure can inactivate B12 Important: Do not take folic acid alone when B12 deficiency is possible or uncorrected, as this may worsen neurological damage Avoid measuring serum B12 immediately after injections due to falsely high results Dietary optimisation remains the preferred approach for those without absorption issues