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In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids
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The side chains of N347 and D350 of G i engage in polar interactions with the main chain carbonyl of A144 and the side chain of K329 of GHSR, respectively (Fig
Some compounded methylcobalamin products may specify storage at room temperature, refrigerated, or frozen prior to mixing
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