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From a biochemical point of view, two essential enzymatic reactions require vitamin B 12 (cobalamin)
Who should consider taking vitamin B12 supplements in the UK
Exposure per milligram is higher, particularly in lighter East Asian users, while the smaller fat reserve makes a 75:25 fat-to-lean split more consequential
Human relevance would require sufficient published, peer-reviewed controlled human studies, appropriate regulatory review, pharmacokinetic characterization, toxicology data, and long-term safety evaluation
Patients who are pregnant or planning to become pregnant should discuss the risks with their clinician before starting treatment
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