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When gain-of-function LRRK2 mutants are anchored to mitochondria, it phosphorylates and traps Rab10 nearby (Gomez et al., 2019), causing decreased interaction of Rab10 with OPTN (optineurin), which is an autophagy receptor, therefore impairing mitophagy (Wauters et al., 2020)
5-Amino-1MQ Side Effects and Safety Questions Because human safety data is limited, the side effect profile of 5-Amino-1MQ is not fully established
Too Much Vitamin B12 Despite Deficiency
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Questions to Ask Your Medical Spa Provider Before committing to B12 injections, ask your provider specific questions
I chose to use the upper side of my thigh
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