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The absence of these protective effects in SIRT1-knockout mice confirms the mechanisms specificity (95)

however, controlling for age still revealed a strong association with acute brain fog

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To rule out the possibility that lean mass loss following BW reduction could have affected creatinine-based eGFR measurement, the muscle mass-independent endogenous filtration marker cystatin C was used to confirm the renal favorable effects attributed to tirzepatide [52]

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