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glutathione's antioxidant activity may dampen this response Mechanism 4: Thyroid Hormone Metabolism Support Thyroid hormone conversion - the transformation of inactive T4 (thyroxine) to active T3 (triiodothyronine) - is performed by iodothyronine deiodinase enzymes (DIO1, DIO2, DIO3), which are selenoproteins that depend on the glutathione/thioredoxin antioxidant system for their activity and regeneration

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Deficiencies will make themselves known with unpleasant symptoms like lethargy, frequent headaches, brain fog, skin eruptions, sleep or mood disorders, or you may seem to catch a lot of colds

Zhang H, Forman HJ (2012) Glutathione synthesis and its role in redox signaling

Induction of Gpx4 knockout in mice For survival and end-point studies, the tamoxifen-inducible conditional mouse strain Gpx4 fl/fl ROSA26-creERT2 was used as previously described 20

Heat Exhaustion vs Heatstroke The line between heat exhaustion and heatstroke is the difference between a serious warning and a life-threatening emergency