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The 24% average weight loss at 48 weeks approaches what bariatric surgery achieves, and the metabolic improvements extend far beyond the scale

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For women of reproductive age with PCOS, the priority is to simultaneously strengthen fertility planning and contraceptive management while improving ovulatory opportunities, ensuring weight and metabolic stability during the preconception washout period to avoid the maternal-fetal risks associated with a weight lossrebound cycle (133, 137)