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The most common side effects when transitioning GLP-1 medications include: Mild to moderate GI distress Diarrhea Constipation Nausea If certain techniques helped you manage the side effects last time, feel free to use those again

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The STEP 1 trial recorded average drops of 14.9% across 68 weeks, ranking it among the strongest pharmaceutical options today

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But they work in totally different ways: Sermorelin therapy: stimulates the pituitary gland to release growth hormone, which increases IGF-1 and supports bone, muscle, and metabolic function Estrogen therapy: binds to estrogen receptors rather than growth hormone receptors, impacting many of the same tissues, including bones, muscles, and fat As women balance the symptoms that arise during perimenopause and midlife, finding the right solution varies based on personal needs, body type, and other health factors

doi: 10.3390/ijms25126808 99 GuptaSPandakWMHylemonPB