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UK product information advises that patients should: Recognise symptoms of pancreatitis (severe, persistent abdominal pain radiating to the back, nausea, vomiting) Seek immediate medical attention if these symptoms develop Discontinue the medicine if pancreatitis is suspected Not restart the GLP-1 medicine if pancreatitis is confirmed Patients should also be aware of an increased risk of gallbladder disease (gallstones, cholecystitis) with GLP-1 medicines, which can present with similar abdominal symptoms and requires prompt medical attention

NHS and UK medical guidance The UKs National Institute for Health and Care Excellence (NICE) has evaluated the safety profile of tirzepatide, including its risk of pancreatitis, as part of its approval process

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