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A 2025 meta-analysis examining over 142,000 participants found that tirzepatide produced significantly greater weight loss than semaglutide, an average of 4.23% more body weight lost
The colon absorbs more water from the waste because it sits there longer, making stools harder and more difficult to pass
8 Its the same drug as the Wegovy injection, so it mainly suits people who would prefer a daily tablet to a weekly injection, rather than those looking for the most weight loss
They are now used both for people with and without diabetes, particularly when weight is impacting overall health
doi: 10.1056/NEJM197706232962502 25 SonKBLeeTJHwangSS
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