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Unexplained Weight Loss: Despite eating normally, nutrient malabsorption can lead to weight loss over time

MK-677 increases appetite in 6080% of subjects and reduces insulin sensitivity by 1015%, raising fasting glucose 510 mg/dL

While our findings with ErbB2+ GEMMs validated the effects of FAO inhibition using etomoxir, a known CPT1-specific inhibitor, concerns about off-target effects at higher doses call for the development of more specific and effective Cpt1a inhibitors (Fig

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