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In addition, exendin-4 injection enhanced calcium signals in DMH GLP-1R neurons in the pre-ingestive stage, and exendin-4-induced pre-ingestive satiation was mitigated by optogenetic inhibition of DMH GLP-1R neurons
Platts J
Two reasons: Raw ingredient cost: Tirzepatide raw material is more expensive to produce than semaglutide due to its larger, more complex molecular structure (39 amino acids with a C20 fatty diacid moiety)
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