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Thus, using CODA-RET, we were able to disclose, for the first time, a different qualitative profile of several D 2 -like receptor ligands for D 4.4 R and D 4.7 R, but only when forming heteromers with D 2 R or 2A R ( Using CODA-RET, we found two possible mechanisms for the D 4.7 R gain of function as mediator of an inhibition of frontal cortico-striatal neurotransmission ( Figure 1 ): first, a specific increase in the potency of dopamine for the D 2 R-D 4.7 R, but not for D 2 R-D 4.4 R heteromer, as compared with the D 2 R homomer ( 2 R when it was forming D 2 R-D 4.4 R or D 2 R-D 4.7 R heteromers, respectively ( 4 R should not be expected to form heteromers, but homomers, which should be more prevalent with D 4.7 R than with D 4.4 R
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Seborrhoeic dermatitis, psoriatic dermatitis and ichthyosis are also seen in some patients