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The United States plays a pivotal role in this expansion, with widespread adoption of GLP-1 RAs in Type 2 diabetes management

Heres the illustration for the Times article: Search ketogenic diet on the website clinicaltrials.gov and among the several hundred hits4, youll find trials assessing the safety and efficacy of virtually every imaginable chronic disease or disorder: A very much non-exhaustive list, in no particular order, includes autism and autism spectrum disorder, Alzheimers disease, major depressive disorder, multiple sclerosis, alcoholism, brain metastases, traumatic brain injury, rheumatoid arthritis, glioblastoma, anorexia nervosa, Parkinsons disease, heart failure, non-alcoholic fatty liver disease, metastatic pancreatic cancer, polycystic ovary syndrome, and, of course, obesity, insulin resistance, and diabetes

Berberine is a plant-based supplement that's gained a lot of traction on social media as a "natural" way to support blood sugar and metabolic health sometimes even called "nature's Ozempic." But pairing it with a GLP-1 can be risky

10.1371/journal.pone.0095935 PLoS One

By signaling immune cells to reduce excessive inflammatory responses, it helps prevent chronic tissue damage

This tier may also include cases where causation is harder to prove due to limited testing, preexisting conditions, or incomplete medical records