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Because the two pathways use different second messenger systems, combining them produces greater GH output than saturating either receptor alone
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Chakravarthy says
Maximum weight loss: 24.2% at 12 mg/week (Jastreboff et al., 2023)
This complex interplay between IGF-1, GH, and insulin coordinates metabolic regulation across fed and fasted states
doi: 10.1007/s00125-017-4447-4 7 GokeRFehmannHCLinnTSchmidtHKrauseMEngJet al
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