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A recent randomized study comparing structured lifestyle modification (a cornerstone in the currently recommended treatment of NASH) to liraglutide 3 mg/day without lifestyle modifications showed similar reductions in ALT and liver stiffness with no difference in bodyweight variations

The weight loss achieved with GLP-1 receptor agonists typically ranges from 515% of initial body weight, depending on the specific agent and dosage used

A GLP-1R agonist/GIPR antagonist peptide is theoretically possible but few full-length GIP-like antagonists were reported, 60 therefore it requires an array of attempts, at least an alanine-scan experiment of GIP with measuring of affinity

Doctors monitor metformin patients for this kind of side effect

Chilibeck PD, Kaviani M, Candow DG, Zello GA

The ratio of reduced glutathione (GSH) to its oxidized form (GSSG) serves as a fundamental marker of the intracellular redox environment