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Convincing data with sufficient power to detect the risk/benefit profile of their use remain to be illustrated
Type 1 diabetes : GLP-1 receptor agonists are not approved for treating type 1 diabetes
A multifaceted strategy that addresses these common pathways could be key to preventing or reducing the impact of diabetic microvascular complications
More patient studies will be needed to determine if dulaglutide drugs, like Trulicity, increase the risk of blood clots in their users
Additionally, the same study reported a decrease in cigarette smoking among participants who were smokers, suggesting potential cross-substance benefits of GLP-1RAs in this population (Hendershot et al., 2025)
Very high risk: Anabolic agent antiresorptive
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