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Minor soreness at the injection site may occur but usually subsides within a day
Redox compartmentalization and cellular stress
Refrigeration dramatically extends unopened shelf life by slowing hydrolysis kinetics according to the Arrhenius equation: every 10C temperature drop roughly halves the degradation rate
It is also important that the vials should not be exposed to extreme temperatures or direct light, so that the efficacy of their preservative, as well as the reconstituted medications, remains intact
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Every reduction in storage temperature slows the hydrolysis and oxidation reactions that break peptide bonds
