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-blockers, particularly nonselective ones, can diminish the first phase of insulin secretion from pancreatic cells, potentially due to the inhibition of 2-mediated insulin release (Lithell et al., 1992

Cell 138 , 976989 (2009)

Siegel agrees

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Risk Factors That Increase Injection-Site Bruising Age-related skin changes reduce elasticity and vessel support, making older adults more prone to bruising after injections