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However, recent research has raised questions about a possible association between semaglutide and a rare optic nerve condition called non-arteritic anterior ischemic optic neuropathy (NAION)

or 2 kg)

While its unknown if semaglutide has the same effect in humans, anyone with a personal or family history of thyroid cancer should not take oral or injectable semaglutide

The crude HR for vertebral fractures was 0.70 [0.461.07] with no change after full adjustment (HR 0.71 [0.461.11]) when comparing GLP-1 RAs with DPP-4is

3), comparisons are limited due to differences in endpoint definitions across studies: nevertheless, CVOTs results suggest substantial kidney protection with both monotherapy and combination therapy, except for the FLOW trial

Dehydration is a major trigger for generalized itching and is surprisingly common in GLP-1 users who experience appetite suppression and reduced fluid intake