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In animal studies, typically involving rats and mice, doses range from 0.1 to 10 micrograms per kilogram of body weight, administered via intramuscular, subcutaneous, or oral routes
These include slower dose escalation schedules (microdosing protocols starting at 0.25 mg or lower weekly increments), consistent meal timing, avoiding high-fat foods during dose adjustment periods, and co-prescribing antiemetics temporarily if needed
2001;131(9):2515S22S
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