doi:10.1016/j.molmet.2018.05.014 52
Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene that is the direct target of these compounds), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) describe the metabolic terrain a clinician prescribes into
Additional important information includes: your diabetic retinopathy status and recent eye screening results, any history of gallbladder disease, pregnancy status or plans (GLP-1 receptor agonists are not recommended during pregnancy or breastfeeding and should be discontinued at least two months before a planned pregnancy), and any history of severe gastrointestinal disease or gastroparesis
Several symptoms overlap, and knowing which is which prevents unnecessary alarm or, conversely, missing an important thyroid change
Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues
optional blood tests may be advised for better personalization
