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J Biol Chem 293:52815294 Sarikhani M, Maity S, Mishra S, Jain A, Tamta AK, Ravi V, Kondapalli MS, Desingu PA, Khan D, Kumar S et al (2018b) SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis

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The first proposed hypothesis is that astrocyte infection leads to altered metabolic pathways, causing damage to neighbouring neurons that are supported by the infected astrocytes, ultimately resulting in astrocyte-associated glutamatergic dysfunction [33, 34]