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The combination of BMS-704807 and U0126 efficiently suppresses the growth and induces cell death in colon tumor cells Our results suggested that activation of MEK1/2 is a key event for the induction of p70S6K1 phosphorylation in resistance to IGF-1R inhibition

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3b) and NP2 had an average hydrodynamic diameter of 116 nm and a PDI of 0.07 (Supplementary Fig

The cells were cultured in 150 mm 2 culture dishes containing 25 mL media under aseptic conditions in a CO 2 incubator at 37 C