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Escalation phase (weeks 5-12): Doses increased by 2 mg every four weeks

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These services, available in most NHS regions (though access varies locally), offer intensive support including psychological therapy, specialist dietetic input, and consideration for bariatric surgery referral when appropriate

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95% CI 0.670.95)

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3-5 ,

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These included miR885 (upregulated) and IGFBP-5 (downregulated)

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Both medications can affect appetite and weight, but in opposite directionssemaglutide suppresses hunger while Lexapro may slightly increase it in some patients

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